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Leishmania After the Genome by

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Published by Caister Academic Pr .
Written in English


  • Genetics (non-medical),
  • Medical parasitology,
  • Life Sciences - Genetics & Genomics,
  • Parasitology,
  • Science,
  • Science/Mathematics

Book details:

Edition Notes

ContributionsNicolas Fasel (Editor), Peter Myler (Editor)
The Physical Object
Number of Pages330
ID Numbers
Open LibraryOL12290844M
ISBN 10190445528X
ISBN 109781904455288

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  Leishmania is a vector-borne pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that range from disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes, or visceral disease affecting Price: $ Unique and cutting-edge, Leishmania: Methods and Protocols is a valuable guide for both established and novice researchers in the Leishmania field. This book will also be useful to researchers working with other protozoa of the Order Trypanosomatide.   The oral agent miltefosine is FDA-approved to treat CL caused by 3 New World species in the Viannia subgenus [Leishmania (V.) braziliensis, L. (V.) panamensis, and L. (V.) guyanensis], as well as for ML caused by L. (V.) braziliensis, in adults and adolescents ≥12 years of age who weigh ≥30 kg and are not pregnant or breastfeeding during. Visceral leishmaniasis in traveler to Guyana caused by Leishmania siamensis, London, UK. Emerg Infect Dis ; Al-Salem WS, Pigott DM, Subramaniam K, et al. Cutaneous leishmaniasis and conflict in Syria. Emerg Infect Dis ; Monteiro DC, Sousa AQ, Lima DM, et al. Leishmania infantum infection in blood donors, northeastern.

Leishmania parasites primarily reside within macrophages. Although macrophages are an important niche for parasite growth and replication, they are also critical for parasite elimination. Leishmania parasites infect macrophages in two ways: either directly based on interactions between receptors on the surfaces of the parasite and the macrophage or indirectly when macrophages engulf apoptotic.   Leishmania (V.) braziliensis is the New World species most often associated with ML, which can occur years, even decades, after acquisition of infection. The incidence of mucosal involvement associated with CL seems to vary with geography and species/strain. Generally, it is highest in the Amazonian basin and adjacent lower altitudes of Andean. Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a neglected tropical disease (NTD).Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people.   Available in: ania parasites cause a diverse group of diseases endemic to many tropical and subtropical regions of the : $

  Leishmaniasis is a poverty-related disease with two main clinical forms: visceral leishmaniasis and cutaneous leishmaniasis. An estimated 07 . In the human host, Leishmania species are obligate intracellular parasites of mononuclear date, approximately 20 Leishmania species (in the Leishmania and Viannia subgenera) are known to infect humans. Cutaneous leishmaniasis typically is caused by Old World species Leishmania tropica, Leishmania major, and Leishmania aethiopica and by New World species Leishmania . sensu lato cluster. There are a few reports of isolation of Leishmania archbaldi and Leishmania infantum from humans and dogs in Gedaref State, eastern Sudan. The causative parasite for CL in Sudan is Leishmania major zymodeme LON-1 (El Hassan and Zijlstra, ). Vectors Phlebotomus orientalis is the primary vector for transmission of VL in Sudan. Leishmaniasis is a poverty-related disease with two main clinical forms: visceral leishmaniasis and cutaneous leishmaniasis. An estimated 07–1 million new cases of leishmaniasis per year are reported from nearly endemic countries. The number of reported visceral leishmaniasis cases has decreased substantially in the past decade as a result of better access to diagnosis and treatment.